Yvette Tache, PhD

Professor, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA and Senior Research Scientist Department of Veterans Affairs.

Dr. Taché, an Associate Director of the CURE: DDRCC and Director of the Animal Models Core, is a recognized expert in brain-gut interactions and the role of peptides in the mechanisms of stress-related gut dysfunction. Her focus has been on the role of brain peptides in the regulation of autonomic outflow to the gut and the mechanisms through which stress via corticotropin releasing factor (CRF) signaling pathways influence digestive function as it relates to gastrointestinal motor function, gastric ulcers, colitis, visceral pain and feeding behavior using electrophysiological, neuro-anatomical, molecular and pharmacological approaches. Models of psychological and viscerosensory stress using colonic distention and abdominal surgery are used to dissect the neuronal pathways and neurotransmitters altering GI function. Her group made pioneering observations that established the physiological role in the brain of several peptides to influence vagal outflow to the stomach and regulate gastric and colonic function. Dr. Taché has also defined the key role of CRF in mediating gastrointestinal motor alterations occurring during immunological, surgical and physiologic stressors. A recent focus is on the effect of diet-induced obesity on gut microbiota and sensitivity to CCK. During the last funding period, Dr. Taché received the William S. Middleton Award, the highest award given by the research division of the Department of Veterans Affairs. She is presently leading a consortium OT2 grant on the structural and mapping of mammalian colonic nervous system.


Yvette F. Tache
UCLA Med-Div of Digestive Dis, CURE
BOX 951792, VA Greater LA Healthcare Sys Bldg 115, Rm 117B
Los Angeles, CA 90095-1792