Tzung K. Hsiai, MD, PhD

Professor, UCLA Department of Medicine and Bioengineering

Dr. Hsai's research focuses on quantitative approaches to study mechano-signal transduction underlying cardiovascular injury and repair. His laboratory has developed the first quantitative approach to study changes in hemodynamic shear stress and vascular oxidative stress via micro-electromechanical systems (MEMS) sensors. They demonstrated that spatial (∂τ/∂x) and temporal (∂τ/∂t) variations in shear stress modulate post-translational oxidative modifications of low density lipoprotein protein (LDL) via NADPH oxidase-mediated signaling pathways. Their contribution to mechanobiology led to the first textbook to advance the field of mechanotransduction entitled "Hemodynamics & Mechanobiology of Endothelium" in 2010. The  team science focuses on interfacing flexible hybrid electronics with vascular mechanobiology, quantitative understanding of mechanically unstable plaque, and 4-D light-sheet microscopy to elucidate biomechanics underlying cardiac development. With a track record for collaboration, funding, and industrial partnership, their  team science has opened up opportunities for team science in a wide range of quantitative sciences, biomedical and clinical research in the UCLA Healthcare System. The lab has uncovered that oxidized lipids and macrophages caused distinct electrochemical properties in the vessel wall that can be measured by Electrochemical Impedance Spectroscopy (EIS). Their multi-disciplinary research has been enriched by experts from UCLA/VA Digestive Disease (Pisegna), Clinical Nutrition (Zhaoping Li), and microbiota and atherosclerosis (Mohamad Navab, Alan Fogelamn, and Aldons J. Lusis).In this context, we are looking forward to collaborating with a cadre of investigators in the CURE Digestive Diseases Research Center.