Patrizia Germano, MD

Dr. Germano studies the effects of PACAP and PAC1 on the signal transduction pathways involved in the activation and proliferation/apoptosis and cytokine release responses in normal and transformed T cells.  Several neuropeptides are released in the gut, which is also the largest T cell compartment in adults. T cells are very important for the maintenance of gut tolerance to food antigens, defense against external invading hosts and surveillance against cancer cells. Dr. Germano’s long-term goal is to elucidate the mechanisms by which neuropeptides and their receptors modulate T cell mediated responses and to understand the modalities by which the immune and the nervous system can communicate.