- About CURE
Oscar Joe Hines, MD
Professor and Chief, Division of General Surgery, Department of Surgery, David Geffen School of Medicine at UCLA
Dr. Hines is exploring the hypothesis that pancreatic cancer tumorigenesis and metastasis may be promoted, in part, by CXC chemokines through stimulation of the CXCR2 receptor. Alteration in the CXCR2 stimulation will alter tumorigenesis and may serve as a potential target for therapeutic intervention in these patients. His aims are: (1) To test the hypothesis that CXCR2 stimulation promotes pancreatic cancer cell growth and that this growth is independent of K-ras mutational status; (2) To inhibit CXCR2 stimulation in pancreatic cancer cells at a molecular and cellular level and determine the effects on tumorigenesis, angiogenic activity, tumor vascular density, and metastatic potential; (3) To determine the influence of host CXCR2 hetero- and homozygosity on pancreatic cancer tumorigenesis, tumor vascular density, and metastatic potential; (4) To establish that human specimens of PaCa demonstrate an imbalance in the expression of angiogenic ELR+, as compared to angiostatic ELR- CXC chemokines, and that this imbalance is directly correlated to tumor-derived angiogenesis. Dr. Hines has been a recipient of a Pilot and Feasibility award of the Center.