- About CURE
Olga Mareninova, PhD
Assistant Research Scientist, VAGLAHS
Dr. Mareninova focuses on the signaling mechanisms involved in the regulation of cell death pathways (i.e. necrosis, apoptosis, autophagy) in pancreatitis. Parenchymal necrosis is a major complication of pancreatitis; also, the severity of experimental pancreatitis correlates directly with necrosis and inversely with apoptosis. Recent results have identified several critical mediators of acinar cell death which determine the balance between apoptotic and necrotic death responses in pancreatitis. The research of Dr. Mareninova identified key molecules in the apoptotic pathway, including caspases and the endogenous caspase inhibitor X-linked inhibitor of apoptosis protein (XIAP). Interestingly, the inhibition or activation of these elements can shift the death response towards apoptosis. This research may identify novel targets to treat or mitigate parenchymal necrosis in pancreatitis. Neither Past Collaborators nor Past Core Utilization is listed because Dr. Mareninvoa is a new CURE: DDRCC Member. She was the recipient of a Pilot and Feasibility Study and was successful in securing extramural funds.