- About CURE
Iordanis Karagiannides, PhD
Assistant Professor, Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen Department of Medicine at UCLA
Dr. Karagiannidis is interested in adipocyte differentiation and fat tissue physiology. The main objective of his research is to define the involvement of abdominal fat tissue in the generation of inflammation during IBD. While the molecular basis of the crosstalk between mesenteric adipose and the inflamed intestine in Crohn's disease (CD) is largely unknown, novel evidence implicates neuropeptides along with adipocyte-derived paracrine mediators (adipokines) as potential targets for future investigations and highlight adipose tissue physiology as a potential important determinant in the course of CD. Dr. Karagiannidis found that fat cells respond to pro-inflammatory stimuli, including the neuropeptide substance P, shown to be expressed during IBD. Substance P-stimulated adocytes, in turn, produce inflammatory cytokines themselves. Such cytokines have also been shown to be involved in CD pathophysiology. His goal is to ultimately achieve additional results through his research and demonstrate whether fat cells actively participate in the events taking place in the colonic lumen during IBD.