Donald Loo, PhD

Associate Research Physiologist, Department of Physiology, David Geffen School of Medicine at UCLA

Dr. Loo research focus has been in the relationship between protein structure and physiological function of ion driven cotransporters, in particular, the sodium-dependent glucose (SGLT1) and proton-dependent oligopeptide (PEPT1) cotransporters. These are largely responsible for the absorption of sugars, amino acids and water across the apical membrane of the intestine. A major approach used by Dr. Loo is to express the cloned transporters in Xenopus laevis oocytes and use simultaneous electrophysiological and optical methods to characterize the kinetics of cotransport. The goal is to understand how these proteins can transport substrates against their concentration gradients.