David R. Scott, PhD

Professional Researcher, Department of Physiology, David Geffen School of Medicine at UCLA

Dr. Scott’s studies have evolved from structural analysis of H,K,ATPase to functional studies of acid secretion by isolated parietal cells to studies of isolated ECL cells.  More recently, he has performed a series of investigations of the regulation of the internal pH of Helicobacter pylori. These studies led to the identification of a proton gated urea channel that is required for acid survival of H. pylori. He determined that internal urease controls viability of this organism in a low pH environment and that the urease activity is manifest at much lower range in viable organisms than in purified urease. Using microarray technology he has identified another protein, α-carbonic anhydrase that is required for acid survival of H. pylori. This protein is localized to the inner membrane and may act in concert with intrabacterial urease to buffer the periplasm of H. pylori thus allowing survival in the gastric milieu. Dr. Scott has been a recipient of the CURE: DDRCC  Pilot and Feasibility award.

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